Journal article
Genetic and Environmental Causes of Variation in the Difference Between Biological Age Based on DNA Methylation and Chronological Age for Middle-Aged Women
S Li, EM Wong, JHE Joo, CH Jung, J Chung, C Apicella, J Stone, GS Dite, GG Giles, MC Southey, JL Hopper
Twin Research and Human Genetics | Published : 2015
DOI: 10.1017/thg.2015.75
Abstract
The disease- and mortality-related difference between biological age based on DNA methylation and chronological age (Δage) has been found to have approximately 40% heritability by assuming that the familial correlation is only explained by additive genetic factors. We calculated two different Δage measures for 132 middle-aged female twin pairs (66 monozygotic and 66 dizygotic twin pairs) and their 215 sisters using DNA methylation data measured by the Infinium HumanMethylation450 BeadChip arrays. For each Δage measure, and their combined measure, we estimated the familial correlation for MZ, DZ and sibling pairs using the multivariate normal model for pedigree analysis. We also pooled our es..
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Grants
Awarded by National Cancer Institute
Funding Acknowledgements
The authors thank the twins and sisters who participated in this study. This research was facilitated through the Australian Twin Registry, a national research resource in part supported by a Centre for Research Excellence Grant from the National Health and Medical Research Council of Australia. This study was supported by the National Health and Medical Research Council of Australia (grant number 1050561 and 1079102), Cancer Australia and National Breast Cancer Foundation (grant number 509307), and Kaiser Permanente (grant number R01CA168893/115-9278/1278-01). John Hopper is a Senior Principal Research Fellow and Melissa Southey is a Senior Research Fellow of the National Health and Medical Research Council of Australia.